Nigepan rectal suppositories 1000m/50mg №5×2

Name:
Nigepan supp.rect. 1000ME0.05g in box No. 5×2
Description:
Suppositories of white or white color with a yellowish tint, torpedo-shaped. The main active ingredient Heparin sodium + benzocaine Release form suppositories Dose 1000 IU 0.05 g Pharmacological properties Pharmacodynamics Combined drug for external use, the action of which is due to the properties of its constituent components. Heparin is a direct-acting anticoagulant that belongs to the group of medium molecular weight heparins. When applied externally, it has a local anticoagulant, moderate anti-inflammatory effect. Benzocaine has a local anesthetic effect. Pharmacokinetics When applied topically, heparin is slightly absorbed. Communication with plasma proteins – up to 95%. It does not cross the placenta and into breast milk. It is metabolized in the liver with the participation of N-desulfamidase and platelet heparinase. Desulfated molecules under the influence of kidney endoglycosidase are converted into low molecular weight fragments. The half-life is on average 1.5 hours. It is excreted by the kidneys, mainly in the form of inactive metabolites. Benzocaine is practically not absorbed when applied topically. Indications for use Thrombosis of external and internal hemorrhoids. Dosing and Administration Rectally. The suppository is introduced into the rectum after a spontaneous bowel movement or cleansing enema. Apply 1 suppository 2 times a day. The course of treatment is 10-14 days. When using rectal suppositories, abdominal cramps and an urge to defecate often occur, so before the procedure, perform a cleansing enema or empty the intestines naturally. Wash your hands thoroughly with soap. Prepare wet wipes or a handkerchief soaked in water in advance. Lie on your side with your knees pressed to your stomach. For the procedure, this position is the most convenient, as it allows you to minimize discomfort. Remove the candle from the package. The candle is taken with the thumb and middle fingers of the right hand in the middle of the widest part, the index finger rests on the blunt end of the candle. The candle is directed with the free end to the anus and pushed with the index finger into the anal canal until it is completely immersed to a depth of 2-3 cm. Carry out the procedure carefully, without exerting excessive pressure. Despite the fact that the suppository has a streamlined shape, careless use can injure the mucous membrane. Do not get out of bed for about 20 minutes. Wipe your hands with a pre-prepared damp cloth or handkerchief. If within 10 minutes after the introduction of a rectal suppository there is an urge to defecate, empty the intestines and introduce a new suppository. If more than 10 minutes have passed between the introduction of the suppository and a bowel movement, an additional dose of the drug is not required. Use during pregnancy and lactation The safety of Nigepan® during pregnancy and lactation has not been established. Precautions When used in combination with other anticoagulant agents, careful monitoring of blood coagulation parameters is necessary. If the existing symptoms of the disease do not decrease during treatment, if anal bleeding occurs, blood is suspected in the stool, and if new unusual symptoms appear, you should consult a doctor. When using the drug Nigepan®, it is necessary to monitor the hygiene of the anal area, avoid excessive stress, take measures to maintain a soft stool consistency. Use with caution in patients with heart block. Use in children The safety of Nigepan® in children under 18 years of age has not been established. Influence on the ability to drive vehicles or other mechanisms The use of the drug does not affect the ability to drive a car or work with machinery. Interaction with other drugs No clinically significant interactions with other drugs have been found. Benzocaine is metabolized to para-aminobenzoic acid, which may interfere with the effects of sulfonamides. Contraindications Hypersensitivity to the components of the drug, bleeding disorders, thrombocytopenia, hypocoagulation; heparin-induced thrombocytopenia at present or in history; childhood. One suppository contains: active ingredients: sodium heparin – 1000 IU (8.3 mg with sodium heparin activity 120 IU / mg), benzocaine – 50 mg; excipients: water – 19.5 mg; solid fat (Witepsol, Supposir) – to obtain a suppository weighing 1.25 g, distilled monoglycerides (Palsgaard 0093) – up to 5% to the amount of solid fat. Overdose There is no information on cases of overdose. Side effects Evaluation of undesirable adverse reactions is based on the following data on the frequency of occurrence: very often (> 1/10), often (> 1/100 to < 1/10), infrequently (> 1/1000 to < 1/100), rarely ( > 1/10000 to < 1/1000), very rare (< 1/10000), not known (cannot be estimated from the available data). Blood and lymphatic system disorders: Not known: thrombocytopenia. Immune system disorders: Infrequently: hypersensitivity reactions are possible, including redness, swelling, itching. General disorders and disorders at the injection site: Not known: burning sensation in the anus, a slight increase in bleeding in the first 3 days of use. In case of occurrence of any undesirable phenomena, it is necessary to stop using the drug and consult a doctor. Storage conditions In a place protected from light at a temperature not exceeding 20 ° C. Keep out of the reach of children. Buy Nigepan rectal suppositories 1000m/50mg No. 5x2 Nigepan rectal suppositories 1000m/50mg No.5x2