Moxonidine tablets p/o 0.2mg №10×3

Moxonidine Tablets p/o 0.2mg №10×3: Effective Blood Pressure Management

Looking for a reliable and effective treatment for high blood pressure? Moxonidine tablets p/o 0.2mg №10×3 offer a proven solution for managing arterial hypertension. This comprehensive guide provides detailed information about this medication, including its uses, dosage, potential side effects, and safety precautions.

Product Description:

Moxonidine Amantismed is a centrally-acting antihypertensive medication available in film-coated tablets.

Key Features:

• Active Ingredient: Moxonidine (0.2mg per tablet)
• Form: Round, biconvex tablets, white in color
• Pharmacological Action: Moxonidine acts as an α2-adrenergic receptor agonist, leading to a reduction in systemic vascular resistance and blood pressure.

Indications for Use:

Moxonidine tablets are primarily indicated for the treatment of arterial hypertension.

Dosage and Administration:

• Usual Starting Dose: 0.2mg daily, taken orally with water, preferably in the morning.
• Maximum Daily Dose: 0.6mg, divided into two doses (morning and evening).
• Maximum Single Dose: 0.4mg.
• Dosage Adjustment: The dosage should be tailored to individual patient needs. For insufficient therapeutic effects, the dose may be increased after 3 weeks of therapy to 0.4mg twice daily.
• Discontinuation: Treatment should not be stopped abruptly. The medication should be withdrawn gradually over 2 weeks.

Precautions:

• Renal Impairment: In patients with moderate renal insufficiency, the initial dose is 0.2mg daily. Careful dose titration is recommended.
• Hepatic Impairment: No studies have been conducted in patients with hepatic impairment. However, moxonidine is minimally metabolized by the liver, so minimal impact on pharmacokinetics is expected. Dosage in patients with mild to moderate hepatic insufficiency remains the same as for adults.
• Elderly Patients: Dosage regimen is similar to adults with normal renal function.
• Children and Adolescents: Moxonidine is not recommended for individuals under 18 years old due to insufficient safety and efficacy data.
• Driving and Operating Machinery: Side effects like dizziness and drowsiness may impair alertness and reaction time. Exercise caution when driving or operating potentially dangerous machinery.

Side Effects:

Common side effects include headache, dizziness, drowsiness, dry mouth, and nausea. Less common side effects may include bradycardia, hypotension, rash, and itching.

Contraindications:

Moxonidine is contraindicated in individuals with:

• Hypersensitivity to moxonidine or any excipients
• History of angioedema
• Sick sinus syndrome or sinoatrial block
• Atrioventricular block of 2nd or 3rd degree
• Bradycardia (heart rate below 50 beats per minute at rest)
• Malignant arrhythmia
• Heart failure
• Severe ischemic heart disease or unstable angina
• Severe liver failure
• Chronic renal failure (creatinine clearance < 30 ml/min)
• Hereditary galactose intolerance, lactase deficiency, or glucose-galactose malabsorption
• Pregnancy or breastfeeding
• Children and adolescents under 18 years old

Overdose:

Overdose symptoms may include headache, sedation, drowsiness, hypotension, dizziness, asthenia, bradycardia, dry mouth, vomiting, fatigue, and epigastric pain. Treatment usually involves supportive measures, including fluid administration, dopamine, atropine, and alpha-adrenergic antagonists.

Interactions with Other Drugs:

Moxonidine can interact with other medications, including:

• Antihypertensive Drugs: Enhances antihypertensive effects.
• Tricyclic Antidepressants: May reduce the effectiveness of moxonidine.
• Tranquilizers, Alcohol, Sedatives, and Hypnotics: May increase sedative effects.

Storage:

Store in a dry, light-protected place at a temperature not exceeding 25°C. Keep out of reach of children.

Availability:

Moxonidine tablets p/o 0.2mg №10×3 are available by prescription only.

Please consult your doctor or pharmacist for further information and personalized advice regarding moxonidine therapy.

Keywords:

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Note: This information is for general knowledge and informational purposes only, and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment of any medical condition.