Glucose solution for infusions 50mg/ml in polymer containers 250ml №1

Glucose Solution for Infusion 50mg/ml: Essential Information and Safety Guidelines

This comprehensive guide provides detailed information on Glucose solution for infusion 50mg/ml, a vital medical solution used to replenish glucose levels in various clinical situations. We cover key aspects including administration, safety, potential interactions, and contraindications.

What is Glucose Solution for Infusion 50mg/ml?

Glucose solution for infusion 50mg/ml is a sterile, non-pyrogenic solution containing 50mg of anhydrous glucose per milliliter. It’s available in polymer containers of 250ml and is commonly used in hospitals and medical settings to:

• Correct hypoglycemia: This solution effectively raises blood sugar levels in patients experiencing low blood sugar.
• Provide essential energy: Glucose is a primary source of energy for the body, and this solution can provide vital fuel during illness, surgery, or trauma.
• Support fluid balance: The solution can also be used to help rehydrate patients suffering from dehydration.

Important Administration Guidelines:

• Visual inspection: Before administering the solution, always perform a visual inspection of the container. The solution should be clear, free from suspended particles or sediment. Ensure the label is present and the packaging is sealed.
• Dosage and infusion rate: The concentration and dosage of the solution depend on the patient’s age, body weight, and clinical condition. Dosage is determined by a medical professional, and the infusion rate should not exceed the patient’s glucose utilization threshold to avoid hyperglycemia.
• Monitoring: Carefully monitor clinical and biological parameters, especially blood glucose concentration and water-salt balance.
• Insulin considerations: For better glucose assimilation when administering large doses, insulin may be prescribed simultaneously at a rate of 1 IU of insulin per 4-5 g of glucose.

Safety and Precautions:

• Hyperglycemia risk: Prolonged use of glucose solution can lead to hyperglycemia. Careful monitoring is crucial.
• Brain injury: Avoid prescribing glucose solution in the acute period of severe traumatic brain injury or acute cerebrovascular accident.
• Electrolyte balance: Monitor water and electrolyte balance during treatment.
• Pregnancy and lactation: Exercise caution during pregnancy and lactation, as glucose solutions can cause fetal hyperglycemia and metabolic acidosis.
• Kidney and heart issues: Use with caution in patients with renal or cardiac insufficiency.
• Hypokalemia: Combined administration with potassium supplements is necessary to prevent worsening hypokalemia.
• Administration method: Do not use subcutaneously or intramuscularly. Administer slowly through large veins to prevent thrombophlebitis.

Interactions with other Drugs:

Glucose solution is incompatible with several medications, including:

• Aminophylline
• Soluble barbiturates
• Erythromycin
• Hydrocortisone
• Warfarin
• Kanamycin
• Soluble sulfonamides
• Cyanocobalamin
• Blood products

Contraindications:

Glucose solution 50mg/ml is contraindicated in patients with:

• Intracranial and intraspinal hemorrhages (except for hypoglycemia-related conditions)
• Severe dehydration, including alcoholic delirium
• Hypersensitivity to dextrose or other components of the drug
• Anuria
• Diabetes mellitus and other hyperglycemic conditions
• Hyperlactacidemia, hyperosmolar coma
• Hyperhydration, cerebral and pulmonary edema, acute left ventricular failure
• Circulatory disorders threatening brain and lung swelling

Use with caution in patients with:

• Decompensated chronic heart failure
• Chronic renal failure (oligo-, anuria)
• Hyponatremia
• Diabetes mellitus

Overdose:

Overdose may cause hyperglycemia and hyperhydration. Symptoms include:

• Dry skin and mucous membranes
• Decreased eyeball tension
• Frequent shallow breathing without acetone odor
• Tachycardia, arrhythmia
• Loss of consciousness
• Increased body temperature

Side Effects:

Common side effects include:

• Hypervolemia
• Acute left ventricular failure
• Osmotic diuresis
• Infection and thrombophlebitis at the injection site
• Electrolyte imbalance (hyponatremia, hypokalemia, hypophosphatemia, hypomagnesemia)
• Hyperglycemia
• Allergic reactions (hyperthermia, skin rash, angioedema, shock)
• Vein thrombosis
• Nausea

Storage Conditions:

Store at temperatures between 5°C and 30°C. Do not freeze. Keep out of reach of children.

Important Note: This information is intended for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before using any medication or treatment.

For more information on Glucose solution for infusion 50mg/ml, please contact a healthcare professional.